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Malegra FXT Plus is a medication that contains the active ingredients Sildenafil citrate and Fluoxetine. It is a combination medication designed to address two different sexual health concerns: erectile dysfunction (ED) and premature ejaculation (PE). ildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that works by increasing blood flow to the penis during sexual stimulation. This helps men with ED achieve and maintain an erection.