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Zhewitra is a medication used to treat erectile dysfunction (ED) in men. It typically contains vardenafil as its active ingredient. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor, similar to sildenafil (Viagra) and tadalafil (Cialis). These medications work by increasing blood flow to the penis, facilitating an erection during sexual stimulation. Zhewitra usually contains vardenafil as the active ingredient. Vardenafil works by inhibiting the enzyme PDE5, leading to increased levels of cyclic guanosine monophosphate (cGMP), which promotes relaxation of smooth muscle cells in the blood vessels of the penis.