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Vilitra works by blocking the PDE5 enzyme, which normally limits blood vessel relaxation. When this enzyme is inhibited, the smooth muscles in the blood vessels of the penis relax, allowing increased blood flow during sexual arousal. It does not cause an erection on its own and requires sexual stimulation to be effective. It is usually taken about 25 to 60 minutes before sexual activity, and its effects typically last for around 4 to 6 hours, depending on the dose, metabolism, and overall health of the user. It can be taken with or without food, although very heavy or fatty meals may slow down its onset.