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Cenforce D is a combination prescription medication used to treat erectile dysfunction (ED) and sometimes to help with premature ejaculation. It contains two active ingredients: sildenafil citrate, a PDE-5 inhibitor that improves blood flow to the penis, and dapoxetine, a selective serotonin reuptake inhibitor (SSRI) that helps delay ejaculation. Sildenafil: During sexual arousal, the body releases nitric oxide, which increases cyclic GMP (cGMP) in the penile tissue. cGMP relaxes smooth muscles in blood vessels, allowing more blood to flow into the penis. Sildenafil blocks the PDE-5 enzyme that breaks down cGMP, helping maintain an erection.