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Vilitra 40 mg can cause side effects. Common reactions include headache, flushing, stuffy nose, upset stomach, dizziness, and mild back pain. These effects are typically temporary. However, more serious symptoms—such as sudden vision or hearing loss, irregular heartbeat, chest pain, or an erection lasting longer than four hours—require immediate medical attention. Individuals taking nitrates, alpha-blockers, or medications for heart disease should avoid Vilitra due to potentially dangerous interactions.