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Common side effects of Vilitra include headache, flushing, nasal congestion, and dizziness. However, priapism is less common and occurs only rarely. According to clinical data and FDA guidelines, the incidence of priapism related to PDE5 inhibitors is very low, but it remains a crucial safety warning because of its severity. Diseases like sickle cell anemia, leukemia, multiple myeloma, or other blood disorders can predispose users to priapism.