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Malegra is another brand name for a medication that contains Sildenafil Citrate, which is primarily used to treat erectile dysfunction (ED), much like Tadalista (which contains Tadalafil). Sildenafil, the active ingredient in Malegra, works by increasing blood flow to the penis, helping men achieve and maintain an erection when sexually aroused. Sildenafil is a PDE5 inhibitor, meaning it blocks the enzyme phosphodiesterase type 5 (PDE5), which normally works to constrict blood vessels in the penis. By inhibiting this enzyme, Sildenafil helps the blood vessels relax, allowing more blood to flow to the penis, which is essential for an erection.