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Malegra is an effective medication for treating erectile dysfunction, improving blood flow to the penis and helping men achieve an erection during sexual activity. As with any medication, it is essential to follow the prescribed dosage and consult a healthcare provider before use, especially if you have underlying health conditions or are taking other medications. Sildenafil Citrate works by inhibiting the enzyme PDE5 (phosphodiesterase type 5). Inhibition of PDE5 helps to increase the levels of cGMP (cyclic guanosine monophosphate), a substance that relaxes the smooth muscles of the blood vessels in the penis.