If you wish to contact tatreperde by e-mail, please register or log in.

Sildenafil, the active ingredient in Manforce, works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This inhibition increases levels of cyclic guanosine monophosphate (cGMP), which relaxes the blood vessels in the penis, allowing for increased blood flow and an erection in response to sexual stimulation.