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Sildenafil citrate in Zenegra 50 mg works by inhibiting the PDE5 enzyme, which is responsible for breaking down cyclic guanosine monophosphate (cGMP). cGMP plays a critical role in relaxing the smooth muscle in the blood vessels of the penis. When a man is sexually stimulated, increased levels of cGMP lead to enhanced blood flow to the penis, resulting in an erection.
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