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Tadarise 60mg works best when taken an hour before sexual problems. You may not get an erection until you are sexually excited. The erection can go away unaided once you have had a sexual experience. The effects of the medicines last in the body for 36 hours, so you will see the effect of the medicine for more than a day One tablet of the medicine has to be swallowed with water before participating in sexual activities. It is suggested that the user take the Tadarise 20 mg (Tadalafil) tablet approximately 30 to 60 minutes before engaging in sexual intercourse. The drug takes about 30 minutes to begin working.