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Malegra DXT is a medication that combines two active ingredients: Sildenafil and Duloxetine. It is often prescribed for the treatment of erectile dysfunction (ED) and premature ejaculation (PE) in men. Sildenafil: This is the same active ingredient found in Viagra. It works by increasing blood flow to the penis, helping to achieve and maintain an erection. Duloxetine: This is an antidepressant from the selective serotonin-norepinephrine reuptake inhibitor (SSNRI) class, which also helps in delaying premature ejaculation by increasing serotonin levels in the brain.